- 产品详情
- 产品参数
人 PBX1 (NM_002585) ORF克隆产品信息
订购信息
| 货号 | 种属 | 载体 | 描述 | 价格 | 周期 |
| YHO10172 | Human ORF | pLVX-IRES-Puro | Homo sapiens pre-B-cell leukemia homeobox 1 (PBX1), transcript variant 1, mRNA NM_002585 | 3500 3000 | 3-4 周 |
基本信息
| 基因名称： | PBX1 |
| NCBI序列号： | NM_002585 |
| 基因描述： | Homo sapiens pre-B-cell leukemia homeobox 1 (PBX1), transcript variant 1, mRNA NM_002585 |
| 基因种属： | Human |
产品说明书
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载体信息
基因简介
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
