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人 WISP2 (NM_003881) ORF克隆产品信息
订购信息
| 货号 | 种属 | 载体 | 描述 | 价格 | 周期 |
| HO003881 | Human ORF | pDoubleEx-EGFP | Homo sapiens WNT1 inducible signaling pathway protein 2 (WISP2),transcript variant 3, mRNA NM_003881 | 3000 | 2-3 周 |
基本信息
| 基因名称： | WISP2 |
| NCBI序列号： | NM_003881 |
| 基因描述： | Homo sapiens WNT1 inducible signaling pathway protein 2 (WISP2),transcript variant 3, mRNA NM_003881 |
| 基因种属： | Human |
产品说明书
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载体信息
基因简介
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
