- 产品详情
- 产品参数
小鼠 SMAD4 (NM_008540) ORF克隆产品信息
订购信息
| 货号 | 种属 | 载体 | 描述 | 价格 | 周期 |
| YMO10103 | Mouse ORF | pYr-CMV-Kan | （C端带flag标签）Mus musculus SMAD family member 4 (Smad4), mRNANM_008540 | 3500 | 1-2 周 |
基本信息
| 基因名称： | SMAD4 |
| NCBI序列号： | NM_008540 |
| 基因描述： | （C端带flag标签）Mus musculus SMAD family member 4 (Smad4), mRNA NM_008540 |
| 基因种属： | Mouse |
产品说明书
请联系YRgene技术支持索取产品说明书。
基因简介
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
