- 产品详情
- 产品参数
小鼠 DNMT3L (NM_019448) ORF克隆产品信息
订购信息
| 货号 | 种属 | 载体 | 描述 | 价格 | 周期 |
| MO019448 | Mouse ORF | pYr-CMV-Kan | （C端带flag标签）Mus musculus DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l),transcript variant 1, mRNA NM_019448 | 3500 | 1-2 周 |
基本信息
| 基因名称： | DNMT3L |
| NCBI序列号： | NM_019448 |
| 基因描述： | （C端带flag标签）Mus musculus DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l),transcript variant 1, mRNA NM_019448 |
| 基因种属： | Mouse |
产品说明书
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基因简介
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
